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- SylSyn
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- Sermon, Erick feat. Khari & Daytona
- Sermon, Erick feat. Redman
- Sermon, Erick feat. Redman & Murray, Keith
- Sermon, Erick feat. Redman, Murray, Keith & Scott, Sy
- Serna, Erick and Killing Floor, The
- Serna, Kevin di
- Serneholt, Marie
- Sero (German hip-hop / rap)
- Sero (German rapper Stefan Hergli)
- Sero & Karen
- Sero El Mero
- Sero.Overdose
- Serocs
- Serok47
- Seroka, Henri (Polish-Belgian composer, producer, vocalist)
- Serotonin Zero
- Serpent (Swedish heavy / doom / hard rock from Vänersborg)
- Serpent Dream (New Zealander James Costin)
- Serpent Omega
- Serpent Power (Feat. Ian Skelly (The Coral) and Paul Molloy (The Zutons))
- Serpenteens
- Serpentfoot
- Serpenti (Italian band)
- SERPENTIN (German alternative singer)
- Serpentina
- Serpentine (British Hard Rock Group)
- Serpentine Path
- Serpentor (Argentine thrash metal band)
- Serpents, House of
- Serpents, House of feat. Battlejuice
- serpentwithfeet
- serpentwithfeet (experimental musician/singer based in Brooklyn)
- serpentwithfeet
- serpentwithfeet feat. Ty Dolla Sign & Yanga Madlala
- Serpentyne (British Symphonic folk-metal band)
- Serpico (Edinburgh, UK punk/metal band)
- SERRA (J-pop singer-songwriter)
- Serra Lima, María Martha
- Serra, Alex
- Serra, Anton
- Serra, Éric (French bassist and score composer)
- Serra, Éric & Serra, Mitivaï
- Serra, Jacobo
- Serrano, Antonio (harmonica)
- Serrano, Ismael (Spanish singer-songwriter & guitarist)
- Serrano, Jorge
- Serrano, José (Spanish composer)
- Serrano, Mariu
- Serrano, Paco
- Serrano, Rosita
- Serrat (Greenland/Danish band)
- Serrat, Joan Manuel
- Serrat, Joan Manuel & Sabina, Joaquín
- Serrat, Joan Manuel con Poveda, Miguel
- Serrat, Joana
- Serrata, Jessy
- Serrie, Jonn
- Serrini
- Sers, Gauvain
- Sershen&Zaritskaya
- Sertab & Murat Uncuoglu & Aytekin Kurt
- Sertkaya, Emre (Turkish singer)
- Serto Mercurio (noise-pop band)
- Sertraline
- Serú Girán
- Serum (Mark Gaunt, UK drum & bass producer)
- Serum 114
- Serushio (Portuguese rock duo)
- Servando y Florentino
- Servant (German black metal band)
- Servant, The (English alternative band)
- Servants, The (UK indie rock band)
- Servat, Gilles
- Served Cold
- Served on Sunday
- Servergent (US rapper)
- Servicentro
- Servo (90s UK punk band)
- serwo
- Seryn
- Seryoga
- Sés (Galician singer, musician and songwriter)
- Ses Snare
- Sesame (Raleigh NC alternative metal)
- Sesame Girl
- Sesame Street (children's TV show)
- Sesame Street Live
- Şeşen, Efkan
- Şeşen, İlhan
- Seshen, The
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